Officials in north-west Afghanistan say at least seven civilians have died in an air strike by international forces.
They say at least 13 insurgents also died in the raid, after they attacked Afghan and international troops in Ghowrmach district in Badghis province.
US-led forces said they were investigating the incident, and regretted any civilian deaths
On Wednesday President Karzai condemned a US air strike which killed 40 people at a wedding in Kandahar province.
Mr Karzai called on Barack Obama to prevent civilian casualties when he take over as US president.
'Ambush'
Officials in Badghis province say fighting between troops and insurgents went on for hours.
"Nato troops called in air support which bombed compounds in the area, killing seven civilians and 15 Taleban," Ghowrmach district governor Abdullah Waqif told AFP news agency.
The provincial police chief gave the same number of dead and said women and children had also been killed and wounded.
Troops from the US-led coalition, the Nato-led International Security Assistance Force (Isaf) and Afghan security forces were responding to "an insurgent ambush", a US military statement said.
"The coalition, Isaf and Afghan authorities are investigating reports of non-combatant casualties in Ghowrmach district last night."
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