Many of them are forced to work as unpaid family helpers, which means that their contribution to the national economy goes unnoticed.
A South Asian organisation has called for urgent action to improve the condition of the women in the region.
The Mahbub ul Haq Human Development Centre has said in a report that South Asian women are treated unequally in all spheres.
A spokeswoman for the centre, Khadija Haq, said that steps should be taken to reserve places for women in government jobs.
The report was released on Monday in the Nepalese capital, Kathmandu.
Discriminatoin
According to the report, gender discrimination in South Asia is among the worst in the world.
It says that a majority of women are deprived of equal access to jobs, education, health, property and justice.
Many of them are forced to work as unpaid family helpers, which means that their contribution to the national economy goes unnoticed.
The report says that women account for two-thirds of the illiterate population of the region.
They have little access to health services, which in turn has resulted in a high maternal death rate.
Pregnancy-related deaths alone number more than 200,000 a year and South Asian women do not enjoy equal parental property rights.
It points out that sons rather than daughters are entitled to inherit the property of their parents.
Jobs
South Asian women also do not enjoy legal equality despite the constitutional guarantees.
It says that in many cases, these guarantees are contradicted by other laws and traditional practices.
The president of the Islamabad-based Human Development Centre, Khadija Haq, said that while some progress has been made in reducing gender inequality in the region, it has been very slow.
She called for the setting aside of a third of the jobs in judiciary, legislature and the executive branches of the government for women.
Named after a noted Pakistani economist, Mahbub ul Haq, the Human Development Centre has been publishing annual reports with the support from the United Nations.