Blood vessel clue offers bypass hope

Scientists at the University of Birmingham are focussing on a key protein which could be responsible for the formation of networks of vessels.

Gene therapy based on the research could provide an alternative for people needing treatments such as coronary artery bypass grafts.

Around 28,000 currently need such treatments each year.

The protein VEGF is important for the formation of blood vessels. It acts as a 'key', and it is important that 'locks', called receptors, are also present in cells.

The Birmingham team, who have a £200,000 grant from the British Heart Foundation for their work, have concentrated on a particular receptor for the protein called VEGF R-1.

It had been thought the receptor did not do anything to help the formation of blood vessels.

But the Birmingham team proved that when it is activated, it leads to the release of nitric oxide molecules which promote blood vessel networks to form

Cancer hope

Laboratory experiments using endothelial cells, which line blood vessels, were carried out.

They showed that when VEGF R1 is blocked from working as it should, blood vessels do not form.

Professor Asif Ahmed told BBC News Online "This could alleviate the need for surgery. You could grow a whole artery. We have already done it in a Petri dish."

"We have agents that will activate VEGF R-1. I don't think using that as a treatment is that far away."

He said the findings could be important in cancer as well as heart disease treatment.

"But in cancer treatment, you don't. It could allow tumour cells to be taken from one site to another.

"If you could block that, you could block tumour growth."

Professor Sir Charles George, medical director at the BHF, said: "Although there have been major advances in surgical techniques to replace narrowed arteries, it is important that we continue to look for alternatives to surgery.

"We look forward to the results of this research that in the long term could improve the quality of life for many heart patients."