High Graphics | BBC SPORT>>
Front Page | World | UK | UK Politics | Business | Sci/Tech | Health | Education | Entertainment | Talking Point | AudioVideo |
Health Contents: Background Briefings | Medical notes |

BBC News Online: Health


Friday, 1 March, 2002, 10:20 GMT

TB breakthrough brings vaccine closer


TB patients in Africa
TB is at epidemic proportions in developing countries
Scientists have made a breakthrough in the battle to find a vaccine for the human and animal killer tuberculosis.

Vetinerary experts have discovered the genetic make-up of the bacteria which causes tuberculosis in cattle - revealed to be 99.9% identical to the kind found in humans.

The find will lead to better testing for TB at an earlier stage in cattle and means things are "on track" for the creation of a vaccine to treat both animals and humans.

Speaking on BBC Radio 4's Today programme Dr Glyn Hewinson, project leader, said: "We are hoping that this will give us the building blocks to develop improved diagnostic tests and vaccines.

Incidents rising

"The options are open once you have made a vaccine."

Tuberculosis caused the death of 8,000 cattle as a result of testing for the disease in the year 2,000.

Incidents of TB have been rising in Britain since 1990 - farmers blame the rise on badgers.

The disease once claimed the lives of thousands of people in the UK, but now only affects a small number due to pasteurisation of milk.

But the cost to the global economy of the disease in cattle is enormous - reaching £2.1bn a year.


" It paves the way for the development of a vaccine which is our ultimate objective "
Elliot Morley

The scientists, an Anglo-French collaboration, sequenced the entire genome, or genetic breakdown, of the TB organism to give them a much better understanding of the disease.

Their discovery quashed the belief that humans originally caught the disease from animals and means it was more likely to be the other way round.

Dr Hewinson said it would mean tests to detect the disease much earlier in cattle were only about three years away.

Epidemic proportions

And the chance of producing a cure-all vaccine could be just 10 years away, he told the Today programme.

There are three vaccines for human tuberculosis which are about to move to clinical trials.

Schoolchildren are still routinely given the BCG vaccine, first introduced in the 1950s, which has been successful in reducing the number of TB cases in the UK.

But in developing countries TB is still a major problem in adults, where the disease has epidemic proportions.

Animal Health Minister Elliot Morley welcomed the breakthrough.

He said: "Bovine TB has been a top priority for the government and I am delighted that, in conjunction with others, such major development has been achieved.

"It paves the way for the development of a vaccine which is our ultimate objective."

The Anglo-French project was helped by funding from the Department of the Environment, Food and Rural Affairs and the Wellcome Trust.


Related to this story:
Pregnant woman triggers TB alert (23 Feb 02 | England) Hospital patients in TB alert (19 Feb 02 | England) TB link to ethnic minority poverty (18 Feb 02 | Health) Infectious diseases on the rise (21 Dec 01 | Health) Patients recalled for TB tests (23 Nov 01 | England) Patients recalled for TB screening (20 Nov 01 | England) TB nurse prompts patient tests (20 Apr 01 | Health)


Internet links: World Health Organisation - TB | Department of the Environment, Food and Rural Affairs | Wellcome Trust |
The BBC is not responsible for the content of external internet sites
High Graphics | BBC SPORT>>
Front Page | World | UK | UK Politics | Business | Sci/Tech | Health | Education | Entertainment | Talking Point | AudioVideo |
Health Contents: Background Briefings | Medical notes |

Back to top | BBC News Home | BBC Homepage | ©