Environmentalists have complained that a key European law on the control of chemicals is being watered down.
The Reach chemicals regulation comes up for a vote on Thursday, a week after the parliament's main political groups agreed a business-friendly compromise.
The law demands thousands of chemicals undergo health tests and that they be registered in a central database.
But Greens say last week's compromise means that many chemicals will slip through the net.
"The bill will actually weaken environmental and health protection as we may end up getting no useful data on almost 20,000 chemicals," said Swedish Green MEP Carl Schlyter in a debate in the parliament on Tuesday.
Substitution principle
Some MEPs and environmentalists are also concerned that the law will fail to ensure that hazardous chemicals are progressively replaced by safer alternatives - an area unaffected by the compromise between the main conservative and socialist groups of MEPs.
REACH IN NUMBERS
Reach stands to revolutionise the use of chemicals in Europe by putting the onus on business to prove that the chemicals they use are safe.
The European Commission initially proposed that 30,000 chemicals manufactured or imported in volumes of more than one metric tonne should undergo tests, at industry's expense.
"Compared to what the Commission proposed, our version is less bureaucratic, more feasible and favours business"
The compromise is also supported by the Liberal group, the Alliance of Liberals and Democrats for Europe.
'Workable' proposal
"Compared to what the Commission proposed, our version is less bureaucratic, more feasible and favours business," said Dutch conservative Ria Oomen-Ruijten.
Industry Commissioner Guenter Verheugen told MEPs that the European Commission had decided in favour of the compromise, while Environment Commissioner Stavros Dimas said it improved the workability of the proposal.
The European Chemical Industry Council (Cefic) said it welcomed the desire to produce an "effective regulatory framework for the safe management of chemicals" but added that some "crucial workability issues" remained to be resolved.
More than 1,000 amendments have been tabled, which will make Thursday's vote a lengthy and complicated affair.
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