Milosevic: Refuses to plead to the charges against him
The trial - the biggest in the tribunal's history - will relate to events in Kosovo, and will involve months of testimony from more than 220 witnesses.
The BBC's Janet Barrie in The Hague says it could take years to produce a verdict.
Mr Milosevic, who is appearing at his third pre-trial hearing, has so far refused to recognise the court's legitimacy.
He described it on Tuesday as "part of the machinery" to commit crimes against his country.
On Monday he launched an attack on the tribunal, when asked to enter a plea, and continued shouting despite the attempts of presiding judge Richard May to silence him.
A new indictment relating to events in Croatia was read to the tribunal on Monday, but chief prosecutor Carla Del Ponte said on Tuesday it would take months to prepare the case for trial.
The February trial will be delayed if Ms Del Ponte succeeds in a bid to have the three trials combined.
Mr Milosevic, who has refused to appoint lawyers, is being represented for the first time by a team of independent lawyers appointed on his behalf.
They argued on Monday that the UN World Court should be asked to rule on whether the international war crimes tribunal has the right to judge Mr Milosevic.
Microphone silenced
Later on Tuesday Mr Milosevic will be asked to speak about the conditions of his detention, said tribunal spokesman Jim Landale.
Monday's clash between Mr Milosevic and Judge May came as the ex-president was asked to plead guilty or not guilty to the amended Kosovo charge.
"I wish to say that the very text of the indictment we just heard shows the indictment is false," Mr Milosevic said.
As Mr Milosevic continued to speak, Judge May turned his microphone off, and told him sharply to stop interrupting.
As Mr Milosevic continued to protest, Judge May told him: "Mr Milosevic will you be quiet please."
A "not guilty" plea was entered on Mr Milosevic's behalf to the amended indictment, which takes into account mass graves found outside Belgrade and adds new charges stemming from sexual violence allegedly committed by Serb soldiers.