The photo shows the view from Lennon's New York home
The photograph was taken by Lennon's widow Yoko Ono and is one of only six prints in existence.
It was taken after Lennon was shot by Mark Chapman outside the Dakota Building in Manhattan in 1980.
It is expected to fetch up to £10,000 for charity at Bonham's auction house.
Another piece of Beatles memorabilia, a four-minute home video taken of the Fab Four in 1967 by David Arrowsmith, is expected to fetch £8,000.
Mr Arrowsmith filmed the band in Newquay after spotting them while they were on location during the filming of Magical Mystery Tour.
He said: "I was on holiday with my family and all of a sudden they went past us in a bus.
"We followed them and then they pulled up at the side of the road."
The film had been left in Mr Arrowsmith's shed for the past 35 years.
Another star lot is the professionally mounted collection of drum heads with signatures of 52 of the world's greatest drummers.
Nirvana's Dave Grohl, Chad Smith from the Red Hot Chilli Peppers, Oasis drummer Alan White and Ian Paice from Deep Purple are just some of the big names who are helping to raise money for charity.
It is expected to raise about £8,000 for the cancer charity BACUP in memory of singer Ian Dury.
A considerable collection of memorabilia from the rock band Iron Maiden will be included and incorporates four cymbals trashed during the bands 1980 UK tour by group member Clive Burr.
Unique
A pair of shoes owned by pop legend Buddy Holly is also up for auction.
The 1950s shoes are valued at £2,000.
One of the more unique items on offer is the original Lord Charles ventriloquist's dummy.
His lifelong companion, manipulator and owner, Ray Alan, recently re-discovered the puppet in his attic.
Lord Charles was a star on UK television in the 1960s and 1970s.
The puppet was replaced by the current model in 1974.
During their time together Lord Charles and Mr Alan have met The Rolling Stones and The Beatles.
The puppet is expected to fetch £6,000.
Other pieces up for sale include the original artwork for the child catchers cloak in the hit film Chitty Chitty Bang Bang.
The picture of the yellow and orange cloak is signed by the child catcher himself, Robert Helpmann, and is valued at up to £200.
A full Praetorian Guard costume uniform from the movie Gladiator (£2,500), a plaque from Moulin Rouge (£400), as well as signatures from Charlie Chaplin (£250) and Clark Gable and Vivien Leigh (£550) are also on offer.