Web design a "fast-moving and fluid area"
Web Wizards - Designers who define the Web will focus on one of the most dynamic areas of contemporary design.
Five designers will be showcased in the event, which runs from 30 November to 21 April.
Organisers say they want to highlight star designers in an area which has been considered too fast-moving and fluid to be analysed by museums.
Pioneers
Designer Joshua Davies was one of the first generation of web design pioneers and has combined commercial work for Sony and Lucent, as well as work on his own personal websites.
Like Mr Davies, Yugo Nakamura has also combined work for companies in Tokyo with designing his own projects.
Liverpool's Daniel Brown got into computers at the age of 11. His family could not afford to buy a computer so he started sneaking into the Learning Methods Unit (LMU) at John Moores University in Liverpool to use them there.
He has since gone on to be at the forefront of a new generation of designers.
Canadian James Paterson and Amit Pitaru from New York have combined their talents to produce image, music and movement by fusing Paterson's love of illustration with Pitaru's background as a jazz pianist.
London-based design company Tomato Interactive completes the work on show.
Their have worked with Sony Japan to produce an artificial life form in the firm's website which constantly mutates.
The result means that every time someone logs on, the logo looks different.
The Design Museum have recently launched their own website for the first time.
The front page is decorated with a specially commissioned piece of work by graphic designer Peter Saville, and offers the user a choice of a flash or html experience.