US shares have fallen back slightly as investors wait for a key vote in the US Senate on a revised version of the $700bn (£380bn) bank rescue plan.
Despite hopes that enough changes have been made to get the bill passed, investors remain nervous.
If the Senate does approve the bill it will still have to go to the House of Representatives, which voted against the first version on Monday.
The Dow Jones index closed down 0.2%, 19.6 points to 10,831.1.
The Nasdaq index moved 1.1% lower to 2.069.4 points.
In Europe shares were mixed, with the UK's FTSE 100 index finishing 1.1% higher at 4,959.6 points while France's key index added 0.6% but Germany's Dax 30 index slipped 0.4%.
Earlier Japan's Nikkei index had ended up 1%, while Australia's main index closed up 4%.
Mixed picture
As the Senate prepared for the crucial vote, other events in another eventful day included:
Political momentum
The new US bail-out package is broadly similar to the first, but includes new measures to help gain Congress's backing.
"People are cautious and they lack confidence that a bailout plan will be a one-stop solution"
One of the new clauses will raise the government's guarantee on savings from $100,000 (£56,000) to $250,000.
To get through the Senate, the bill will require the backing by 60 of the 100 senators.
However, it will then have to return to the House of Representatives on Thursday.
"Blind faith doesn't work this time after Monday's disappointment," said analyst Andre Bakhos, president of Princeton Financial Group.
"People are cautious and they lack confidence that a bailout plan will be a one-stop solution. It won't be."
'Responsible bill'
The BBC's Jonathan Beale, in Washington, says a positive vote in the Senate is likely to give the bill momentum when it goes back to the House.
Presidential candidates John McCain and Barack Obama, who both support Mr Bush's efforts to bail out the economy, say they will return from campaigning to vote in the Senate.
And senior Democrats have pledged to find a bipartisan solution.
HAVE YOUR SAY
However, some members of Congress continue to press for more fundamental changes, such as insurance for bad loans, rather than the removal of the loans from the books of financial companies, says the BBC's Americas editor Justin Webb.
On Tuesday President Bush had warned of "painful and lasting" consequences for the US should Congress fail to agree a rescue plan.
Analysts say the Senate is more likely to pass the bill because senators are not facing the same pressure from voters - who are generally opposed to the bailout - as members of the House.
All representatives face re-election in November compared with only one-third of senators.
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