The new, harder-to-counterfeit bill in reds, yellows, oranges and greens entered US circulation on Thursday.
The $10 makeover follows similar colourisation of the $20 bill in 2003 and the $50 note in 2004.
The $100 bill one of the most popular with counterfeiters - is due to be redesigned in 2007, but there are no plans to change the $1, $2 or $5 notes.
Digital counterfeiters
The US government gives its currency a new look every seven to 10 years in a bid to stay ahead of counterfeiters.
Current estimates put the rate of counterfeit $10 notes in circulation worldwide at fewer than one bill per 10,000.
But digital equipment has made it easier for criminals to produce fake currency. Since 1995, the proportion of digitally-produced counterfeit notes in circulation has grown from 1% of all fake bills detected in the US to about 54% in 2004.
The new $10 bill will give fraudsters more headaches.
It features a new portrait of Alexander Hamilton, a subtle orange background, some red highlights and a host of tiny yellow 10's printed all over the note.
The US government has embarked on a massive awareness and education campaign to ensure people are aware of the new note and its security features. Original $10 bills will remain in circulation alongside their new multi-coloured cousins.
1. Color-shifting ink: Colour changes from copper to green when note tilted - change is more pronounced on new note.
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