The parent company of American Airlines will lose 20,000 workers - spread across American, Trans World Airlines and the American Eagle commuter carrier, the parent company, AMR Corporation.
But the US Treasury Secretary, Paul O'Neill, told Congress that the US government would move swiftly to give aid to the industry, to ensure that the costs of extra safety measures and the increased costs of insurance did not fall on the industry.
The US government has proposed a $5bn handout to help US airlines and assist with insurance liabilities, but has stopped short of the $12.5bn the industry says it needs to stave off bankruptcies.
Pain spreads to Europe
Hours after the US announcements, UK carrier British Airways said it would sack 7,000 people - about 12.5% of its workforce - mothball planes and cut routes because of plunging demand.
United - America's number two airline which is also shedding 20,000 jobs - has been harder hit by the disaster than any of the other carriers.
In addition to losing two of its planes in the suicide bombings, it is more heavily reliant on business travel, expected to be adversely affected by the attacks.
Announcing the cuts, American Airlines Chairman Donald Carty told his workforce: "This is, without a doubt, the most difficult thing I have had to do in my two decades at American."
Boeing cuts
The news followed an announcement from Boeing, the world's biggest jet maker, that it would be slashing 20,000-30,000 jobs by the end of next year in response to other airline cut backs.
British Airways and Virgin Atlantic have urged governments to ensure Europe's carriers are not unfairly disadvantaged when US aid is handed out.
Click here to see how the world's airlines are cutting costs
Some estimates suggest the customer downturn is costing the US airlines $1bn a day.
Long term help
Carriers have said they also need longer term help in tackling increased insurance and fuel costs and tighter security.
The crisis in the industry is already spreading to the firms that depend on airline business.
Honeywell, which makes avionics, the electronic systems used in aircraft guidance, also announced it would be cutting 3,800 jobs, over and above the heavy lay-offs it has made already this year.
Some US airlines have warned that, without a comprehensive rescue package, they may have to start filing for Chapter 11 bankruptcy protection within days.
We profoundly regret that these actions will impact the lives of so many of our highly valued employees
Alan Mulally, Boeing
Shares in US airlines, which have lost nearly half their value since the attacks, made slight gains following news of the government's planned intervention.
Related to this story:
UK airlines call for state aid
(18 Sep 01 | Business)
Air passengers face tighter security
(18 Sep 01 | Business)
Air industry faces bleak outlook
(13 Sep 01 | Business)
US airlines plead for government help
(17 Sep 01 | Business)
Airlines bankruptcy warning
(14 Sep 01 | Business)
Airlines suspend Sri Lanka flights
(18 Sep 01 | South Asia)
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