The OECD says that unless 35 "potential tax havens" agree to strengthen information exchange and transparency, and curtail their offshore banking they could face economic sanctions.
But Mr O'Neill told a Congressional committee that he will seek bilateral treaties to share information on suspected tax dodgers, rather than support curbs on preferential tax regimes for foreign individuals and corporations.
Defensive measures
Mr O'Neill said that the OECD has now agreed not to implement any "defensive measures" against non-members before they come into effect on OECD members themselves.
These systems, which Mr O'Neill said were described by the OECD as "poaching", could simply make for a more attractive investment environment, he said.
"I was troubled by the notion that any country or group of countries should interfere in any other country's decisions about how to structure its tax system," Mr O'Neill told the committee.
Mr O'Neill said the OECD has agreed to drop this stipulation from its definition of which countries should incur sanctions.
An OECD spokesman said that broadly represented the organisation's position, which was agreed at a meeting of its Global Tax Forum in June.
More movement needed?
But the non-OECD member states are understood still to be unhappy with the situation.
Despite more than a month having passed since the forum met, the OECD has yet to make an official statement of its own, leaving the state of negotiations unclear.
Led by Barbados Prime Minister Owen Arthur, the non-member states have complained about double standards.
They say the aim is to cut small developing states out of offshore finance.
And they have pointed out that some OECD members including Switzerland and Luxembourg continue to abstain from agreeing with the plans.
Change of heart
The treasury secretary told the committee, chaired by Democrat Carl Levin, that he hopes to have treaties concluded with at least half of the 35 countries on the OECD's list within a year.
Mr O'Neill said that without such treaties it would remain almost impossible to prosecute tax cheats.
Deadlines
This part of the initiative could act as a barrier to getting information exchange up and running, he said.
The deadline for the 35 non-members - six of whom have already signed up - to come on board has already been moved back to November 2001 from July.
Previous US administrations have backed the OECD initiative to the hilt.
Until Mr O'Neill first mooted a change of heart in May, the OECD had been adamant that the date was not negotiable.