One man has been charged in connection with cocaine with a street value of between £10,000 and £15,000 which was allegedly left on a Swansea bus.
The man, in his twenties and from Pembrokeshire, has been remanded in custody and will appear before magistrates on Monday, say police.
Two other Pembrokeshire men arrested on Friday have been released on bail.
Another man later arrested in Swansea has been charged with possession and will also appear in court on Monday.
A man who was also arrested with him on Saturday in connection with cocaine with an estimated street value of £700 was released on police bail pending forensic analysis.
He will be returning to Swansea police station at a later date.
Police have praised the actions of the bus employees which led to the larger amount of cocaine being recovered.
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