The company has other depots across Wales
The parcel delivery company Home Delivery Network Ltd (HDNL) has confirmed it wants to close its Wrexham depot with the loss of 68 jobs.
The company is the UK's largest home delivery and collection service, delivering 300,000 parcels daily.
It said the Wrexham site needs to close due to the "competitive market place".
The Unite union said it was seeking urgent talks with HDNL to establish the reasons for closure and to "see if we can reverse the decision by managers".
In a statement, HDNL said: "Home Delivery Network confirms it has entered into consultation period with unions regarding the proposed closure of Wrexham depot.
"This decision has been taken in the long term interest of the business and its employees amid a competitive market place.
"We appreciate that this is a difficult time for staff and we are doing everything we can to minimise redundancies and mitigate the impact on those affected."
The company also operates depots in Llandudno, Llanelli and Cardiff.
John Burgham, of Unite, said: "We only know they want to close the site for business reasons.
"We need to know those reasons so that we can see if we can reverse the decision by managers. We are seeking urgent talks with the company."