Lynette White was stabbed more than 50 times by client Jeffrey Gafoor
The trial of 15 people charged over the investigation into the 1988 murder of Cardiff prostitute Lynette White is expected to start in May next year.
Of those accused, 13 are former and serving police officers.
The defendants are accused of being implicated in the outcome of two trials which led to the wrongful imprisonment of three men for murder.
Swansea Crown Court heard on Tuesday the trial will be in the city but will need to be a large venue.
The hearing was told that 50 barristers and solicitors were expected to be involved and it could last up to half a year.
Those charged are accused of conspiring to pervert the course of justice over the inquiry into Ms White's murder.
Ms White, 20, was found stabbed to death in a flat in the docks area of Cardiff on Valentine's Day in 1988.
Three men - Stephen Miller, Yusef Abdullahi and Tony Paris - were convicted of her murder in what became one of Britain's most notorious miscarriages of justice.
In 1992 the convictions of the three jailed men were quashed and they were freed.
Two other men - cousins Ronnie and John Actie - were also charged with murder along with Mr Miller, Mr Abdullahi and Mr Paris, but they were acquitted at the trial at Swansea Crown Court in 1990.
In 2003, Jeffrey Gafoor, a client of Ms White, admitted her murder in 2003 and is serving a life sentence.
At the hearing on Tuesday, the judge, Mr Justice Sweeney ruled the 2011 trial will be heard in Swansea, with the favoured location being the old crown court, in the same courtroom where the first murder trial was held in 1989.
However, investigations are underway into whether a trial of that size can fit into the court room as it was thought there would have to be significant work carried out on the building.