Kate Winslet appeared in Casualty in 1993 - four years before Titanic
Plans to double the amount of BBC network programmes made in Wales will see Crimewatch move to Wales and hospital drama Casualty may follow.
BBC director of Vision Jana Bennett has announced that Wales' share of network TV spend will rise to 5% by 2016.
A final decision on moving Casualty, which is currently made in Bristol, will be made in the new year.
BBC Wales controller Menna Richards said the move would aid Wales' creative industry.
The BBC said the announcement reflected the corporation's efforts to better represent the diversity of creative talent across the UK and improve connections with the audiences it served.
In Wales this means the BBC wants to build a large-scale, sustainable production centre which is focused on drama, factual and music content.
"It will enable BBC Wales and its partners in the independent sector to build on the success of existing network programmes such as Doctor Who, Torchwood and Amazon [produced by Indus Films]," said the BBC
The decision on Casualty will be subject to a detailed financial assessment to ensure the relocation provides value for money.
The possible move has provoked a campaign to keep the hospital drama in Bristol by local newspaper the Evening Post.
Ms Richards said moving long-running productions to Wales would give journalists, feature writers and directors "a great opportunity" to showcase their work across the UK.
"Alongside programmes like Doctor Who, Torchwood and Pobol y Cwm, the potential move of Casualty to Wales could play a central role in our drive to build a sustainable and world class centre of excellence for drama in Wales," she said.
"Casualty is a flagship network show that has, for decades, proved a breeding ground for writing, production and acting talent."
Ms Richards said the move would mean factual production from Wales would grow significantly providing opportunities for in-house teams and a range of Welsh independent television companies.