The head of one of north Wales' biggest employers has warned that the threat to Mostyn docks is a "major blow".
Wings for the plane are due to travel to France through Mostyn
The first wings for the new Airbus superjumbo are due to be transported to France through the Flintshire port next year.
But senior Airbus official Brian Fleet said the decision by ferry company P&O to pull out of the docks has jeopardised his firm's timetable.
Airbus is unsure whether the port will remain commercially viable.
The wings for the plane, the A380, are made at Broughton, Clwyd, where 5,000 staff are employed.
Mr Fleet, senior vice-president of Airbus UK and head of the Broughton operation, said there was "no way" that the wings could be flown to France.
The wings are 38 tonnes each, and are far too heavy to be transported by air.
Airbus is to hold urgent talks with officials at the Flintshire port to see whether the first consignments can be delivered via the docks.
The redevelopment of Mostyn docks cost £17m
The Airbus warning follows the announcement by P&O that it is halting ferry trips between Mostyn and Dublin.
That will leave Mostyn without a company running ferries to Ireland.
Council leaders have said Mostyn will remain a key port, and the docks operator is looking for a new ferry company to replace P&O.
The company has commissioned barges to transport the wings, but Mr Fleet said the first superjumbo flight in early 2005 could be in doubt.