Pop trio N-Dubz scooped two awards at the Mobos in Glasgow winning best UK act and best album.
But group JLS also picked up a pair of awards for best song and best newcomer.
Keri Hilson was awarded best R&B/soul act while best hip hop act was won by rapper Chipmunk who had four nominations on the night.
The ceremony paid tribute to Michael Jackson, with La Toya introducing her brother Jermaine who performed on stage in memory of their sibling.
Jermaine said: "My brother was everything to me. He was a wonderful artist and a wonderful human being.
"I'm here to do what I can, it is part of our responsibility as a family to continue his legacy and keep it alive."
Mobos pay tribute to King of Pop
Best international act and best video were won by Beyonce and Sean Paul was named best reggae artist.
Yolanda Brown won best jazz artist; best gospel act was Victizzle; best African went to Nneka while best DJ was won by Trevor Nelson.
But there was no success for Dizzee Rascal or Tinchy Strider, despite each being nominated for three awards.
Accepting the award for best song for Beat Again, JLS's Marvin Humes said: "The band's success would have been inconceivable just a year ago.
"I just want to say thank you to all our supporters who are here tonight.
"I never thought we would be here. I never thought we'd get nominated, and I never thought we would win two awards."
Speaking after the awards, N-Dubz's MC, Dappy, said rapper Tinchy Stryder should not have been overlooked.
"There's no-one like Tinchy, nobody's doing what he's doing, nobody's got his swagger," he said.
"I'm really upset. He should have won something."
The awards were co-hosted by Radio 1's Reggie Yates and US R&B act Keri Hilson, with the winners chosen by public vote.