About 70 truck drivers at Larkhall could lose their jobs
The Cumbrian based haulier Eddie Stobart has announced it is to close two depots with the loss of 180 jobs.
Almost 100 workers at its site in Larkhall, South Lanarkshire face the axe and about 80 jobs will go in Nottinghamshire.
The firm said the cuts were aimed at producing a more cost-effective service.
South of Scotland MSP Aileen Campbell has written to the Enterprise Minister asking him to intervene.
The workers facing the axe at Larkhall include truck drivers and administration and support staff.
The company has now entered a 30 day consultation period with the unions.
HR director, Sheila Woodbridge, said: "The group is committed to listening to the views of the trade unions and employees affected.
"Redundancies will be discussed, and it would be unfair on all parties to pre-empt any outcomes of this consultation."
Aileen Campbell MSP has asked Enterprise Minister Jim Mather to provide support and assistance for the workers and their families.
She said: "Clearly this will be a very worrying time for all the staff at the site and their families.
"I have asked the Scottish Government get involved in the situation and support the workers at this difficult time.
"Nowhere is immune to the effect of the economic downturn, and the UK Government's failure to tackle high fuel prices clearly hasn't eased the pressure on the haulage industry, which of course has already been affected by closures and redundancies elsewhere in South Lanarkshire."
Clydesdale MSP Karen Gillon said: "This is a devastating blow for the local community.
"The Scottish government must look at how it can support these workers, but it must also look at the wider picture and come up with ways to build the local economy in Lanarkshire. "