The Royal Hospital for Sick Children in Edinburgh is set to move to Little France after the idea won overwhelming backing in a public consultation.
The Royal Hospital for Sick Children's present site
The hospital is now expected to leave its existing Victorian base for a purpose-built home beside the Edinburgh Royal Infirmary within six years.
At least 98% backed the choice of site for the new building.
Scottish national policies indicate children's hospitals should be based alongside adult and maternity services.
Bob Anderson, the interim chairman of NHS Lothian, said: "We would like to thank the public for taking the time to respond as so many did during our consultation process.
"We now look forward to pressing on with the planning of our new hospital to offer the best and most modern care we can for the children and young people of Lothian and the rest of Scotland."