Scotland's First Minister Donald Dewar has died in hospital from a brain haemorrhage after taking ill following a fall outside his official Edinburgh residence.
Here is a timetable charting key events since the emergence of a heart scare earlier this year.
25 April 2000: Donald Dewar, 63, is taken to Glasgow Royal Infirmary's cardiac unit for tests after the discovery of a heart irregularity during a routine check-up.
26 April: Mr Dewar reveals he will have to undergo major surgery to replace a defective heart valve.
27 April: The first minister returns to his office at St Andrew's House, Edinburgh, for a round of routine meetings and paperwork, before taking First Minister's Questions in the chamber in the afternoon.
29 April: Mr Dewar rebuffs accusations he is jumping the queue for his operation, insisting he wants to be treated on the NHS "like everybody else".
7 May: Jim Wallace, Deputy First Minister and leader of the Scottish Liberal Democrats takes over as acting first minister as Mr Dewar is admitted to Glasgow Royal Infirmary for treatment.
8 May: Mr Dewar undergoes a 3.5 hour operation to replace a leaking aortic valve with a mechanical device. His condition after surgery is said to be "stable" as he recovers on a ventilator.
9 May: Staff at the hospital describe the first minister as "relaxed and chatty". He is taken out of the intensive care unit on to a hospital ward and is visited by his two children, Ian and Marion.
17May: Ian Dewar collects his father from hospital after he is discharged and is said to be making "good progress".
16 June: Prime Minister Tony Blair pays a private visit to Mr Dewar during a visit to Glasgow to attend a health summit with the other heads of the devolved administrations.
21 June: In his first public interviews since his surgery, Mr Dewar says he has received a flood of get well messages. He adds that the operation left him "knackered" and he has been walking the streets of his Anniesland constituency under instructions from his doctor to take exercise.
25 June: Mr Dewar reveals he has begun to read ministerial papers at his home and expects to be back at work within a month. He dismisses speculation his illness was brought on by the stress of working long hours and insists he is still the best man for the job.
27 June: Mr Dewar attends an awayday meeting of ministers, officials and advisers at the Houston House Hotel in Uphall, West Lothian.
5 July: Following a series of internal squabbles among Scottish cabinet ministers, the first minister steps in to warn them that they risk being sacked if they fail to settle their differences.
10 August: Mr Dewar makes his first public appearance since his surgery, handing over the keys to a minibus at a disability resource centre in his constituency. He says he is "feeling fine" and "looking forward to getting back to work".
14 August: The crisis surrounding the Scottish Qualifications Authority, which sent out inaccurate or incomplete results to 150,000 exam candidates during the summer, is at its height as the first minister returns to his desk.
7 September: MSPs on all sides applaud Mr Dewar as he returns to the Scottish Parliament's debating chamber following the summer recess. He is formally welcomed back by Presiding Officer Sir David Steel.
11 September: The fuel crisis begins as Mr Dewar uses a speech at the TUC's conference in Glasgow to highlight the government's record on public services.
25 September: Mr Dewar insists Labour will "weather the storms besetting it" and win the next General Election, despite an opinion poll for The Scotsman newspaper suggesting his popularity has waned in Scotland.
5 October: Mr Dewar endures a bruising First Minister's Question Time in the Scottish Parliament with new Scottish National Party leader John Swinney, after which he looks visibly tired. Fears for his health at this stage are officially dismissed.
1730BST, 10 October: The Scottish Executive says Donald Dewar is admitted to hospital "as a precaution" after he trips on the steps outside his official residence.
1940BST, 10 October: Mr Dewar's spokesman David Whitton admits the first minister is "seriously ill" as he is moved to the intensive care unit of Edinburgh's Western General.
2125BST, 10 October: Mr Whitton announces that Mr Dewar is "critically ill and on a life support machine" after suffering internal bleeding to his brain.
11 October: Both Mr Dewar's children are at his bedside and his condition is discussed with medical staff.
1218BST, 11 October: Mr Dewar is officially pronounced dead.
1400BST, 11 October: Mr Dewar's personal spokesman David Whitton announces the first minister's death at a packed news conference at Edinburgh's Western General Hospital. He says Mr Dewar's life support machine will stay on a little longer to allow his children some time with their father.