The Conservatives are reeling from the high-profile defeat of shadow education secretary Tim Collins in Cumbria.
Mr Collins lost his seat to the Lib Dems
Mr Collins lost Westmorland & Lonsdale to Liberal Democrat Tim Farron with a 5.1% swing.
The Conservatives now retain a single seat in the county - Penrith and the Borders, held by David Maclean.
Jamie Reed is Labour MP for Copeland, following the retirement of Jack Cunningham. Mr Collins was one of the stars of the 1997 Conservative intake.
His defeat will be a big blow to Michael Howard and severely weaken his front-bench team.
Mr Farron's victory will be a blow to the Tory front bench
He worked for many years in Conservative Central Office and as a special adviser to cabinet members, including Michael Howard at the Department of Employment.
He was made shadow transport secretary in 2002. A year later, Mr Howard rewarded him with the position of shadow education secretary, working under the shadow secretary of state for public services, Tim Yeo.
Mr Farron said: "We fought it like a by-election, on the basis of some very relevant issues, such as local housing.
"My view is that Westminster is work and Westmorland is home. It's all about being a hard working advocate for the people who put me here - somebody who looks after the constituency, as opposed to playing the Westmorland central office game."
Labour held onto their Barrow and Furness, Carlisle, Copeland and Workington seats, but in each case with a reduced majority.