Conservative leader David Cameron has added the finishing touches to his frontbench team, with David Willetts and Alan Duncan changing jobs.
The reshuffle is likely to continue into next week
Theresa May becomes shadow leader of the Commons and Mr Duncan is made shadow trade secretary.
Mr Willetts, who supported Mr Cameron's leadership rival David Davis, becomes shadow education secretary.
Cheryl Gillan, David Mundell, Hugo Swire and Theresa Villiers enter the shadow cabinet for the first time.
Mr Willetts, nicknamed "two brains" because of his formidable intellect, was previously shadow trade and industry secretary.
KEY SHADOW CABINET JOBS
Leader: David Cameron
Chancellor: George Osborne
Foreign: William Hague
Home secretary: David Davis
Party chairman: Francis Maude
Defence: Liam Fox
Education: David Willetts
Commons leader: Theresa May
Constitutional affairs: Oliver Heald
All posts are shadow posts
BBC chief political correspondent James Landale said: "The message is that supporters of Mr Cameron's rivals in the leadership campaign are all getting decent jobs."
Ms May, like Mr Cameron, has described the Conservative Party as seeming too male and too white.
There are 17 female Tory MPs - 9% of the parliamentary party.
She has called on the party to draw up an "A-list" of its 100 most talented would-be MPs, of whom 50 should be female.
Mr Cameron has since said he believes "head-hunting", "mentoring" and an "A-list of candidates" could help encourage more female and ethnic minority candidates to come forward.
Under the reshuffle, Andrew Mitchell stays as shadow overseas development secretary, while David Lidington remains as shadow Northern Ireland secretary.
Oliver Heald takes over constitutional affairs.
Ms Gillan gets the Wales brief, Philip Hammond goes to work and pensions, and Mr Mundell is spokesman on Scottish affairs.
Chris Grayling has been made shadow transport secretary, Mr Swire looks after culture, media and sport, and Ms Villiers becomes shadow chief secretary to the Treasury.
Meanwhile, Caroline Spelman will shadow Deputy Prime Minister John Prescott.
Andrew Lansley stays on as shadow health secretary and Peter Ainsworth takes on environment, food and rural affairs.
Oliver Letwin becomes the Conservative Party's policy director - a shadow cabinet post.
Former party leader William Hague became shadow foreign secretary on Wednesday.
David Davis stays as shadow home secretary and Liam Fox, who also ran in the recent leadership contest, takes over the defence brief.
Mr Hague said it was a "rare moment" and Mr Cameron deserved the help of "old-timers" like himself.
He told BBC Radio 4's Today programme Mr Cameron had the broadest range of talents of any recent leader.
He also said people were now more willing to listen to the opposition because Labour had been in power for nine years.
On Wednesday, it was also announced that Francis Maude would stay on as party chairman and Lord Strathclyde as shadow leader in the Lords.
But Sir Malcolm Rifkind, who only returned to the Commons this May after an eight-year absence, has quit the shadow cabinet after being overlooked for the foreign affairs brief.
Former chancellor Ken Clarke has been asked to head up a new democracy task force.
And ex-Tory leader Iain Duncan Smith will oversee a new social justice policy group to tackle Britain's "broken society".
Mr Cameron became leader on Tuesday, having beaten Mr Davis in a ballot of Tory party members nationwide. Mr Cameron received 134,446 votes to his rival's 64,398.
On the same day, he appointed his chief whip - West Derbyshire MP Patrick McLoughlin. He replaces David Maclean, who has decided to return to the back benches.
The reshuffle doubles the number of women in the shadow cabinet from two to four.
Desmond Swayne will be Mr Cameron's parliamentary secretary having played the same role for predecessor Michael Howard.
Mr Cameron is likely to continue naming more junior appointments into next week.