Here is the text of Health Secretary Alan Milburn's resignation letter to Tony Blair.
As discussed on Monday I have decided I want to leave the government.
The reshuffle you are making today provides the opportunity to do so.
As I have explained I have found it
increasingly difficult to balance having a young family in the North
East with the demands of being a cabinet minister.
I know this is something you understand and I am grateful for all the support you have shown me in respect [of] my decision.
It has been an enormous privilege to serve in the government for six years, but I have already missed a good bit of my children growing up
and I don't want to miss any more.
It has come down to a choice
between my career in politics and my life with my family.
This is now the right time to go. Not just for Ruth and the children, but
The NHS is now moving forwards. The money is going in and the reforms that you and I have argued for are making an impact.
As you know, this has been a difficult decision for me to take and I leave with real sadness.
It is not a political decision for I support you totally in what you are trying to do. It is entirely personal.
It has been a real privilege to work with people in the health service and with our colleagues in government.
Above all, it has been an honour to have
served you as prime minister.
Your strength of leadership and sense of purpose are a huge asset for our party and are achieving great things for our country.
I have no doubt you will continue to do so and I know we will remain friends.
I wish you, my successor, and all my colleagues the very best as we continue to make the changes necessary to prepare Britain for the future.
Here is the text of Tony Blair's reply.
I want to thank you for what you have done for the government, and also for the straightforward way in which you communicated your decision to leave.
When you came to see me on Monday I was obviously very sorry to hear that you wanted
to leave the government, though I understand the reasons and respect your decision.
I know how much your family means to you, and this is clearly a decision you have taken together.
As secretary of state for health, and before that as chief secretary to the treasury, you have made a major contribution to the success of this government.
The NHS has clearly turned the corner. On every measure, waiting times are now lower than in 1997.
Cancer, cardiac and other key services are improving markedly. The number of nurses and other key professionals is rapidly growing.
As importantly, there is now a clear route map for NHS reform. Power and resources are being devolved to primary care trusts and the new NHS foundation hospitals.
Patient choice, purality of provision, and reform of working practices are all being developed.
These are all reforms which I regard as vital, and I want to thank you for having made such a major contribution to their delivery.
The government, and your successor, will continue to pursue them with vigour and determination.
I wish you, Ruth and your family every success and happiness in the future.