Seventy six people are losing their jobs at a medical equipment company in west Belfast.
Seventy-six jobs are to go at Trivirix
The announcement was made at the US-owned firm Trivirix on Wednesday. The plant at Springvale Business Park will continue to employ 37 people.
The court-appointed administrator said they had made the decision after looking at the company's order book.
It is understood that since Trivirix set up in NI in 1999 it has received about £2.5m in government grants.
A spokesman for the Communication Workers Union said they were working to protect their members at a difficult time.
West Belfast MP Gerry Adams has called on the government to step in and provide support for the company.
"The Department of Enterprise, Trade and Investment along with Invest NI need to honour their responsibilities to the workforce, to west Belfast and indeed to the public at large.
"The British government and Invest NI need to work with the administrator and provide investment to sustain the plant and support the employees until a new owner can be found," he said.
The SDLP's Alex Attwood described the news as a body blow.
"The government and Invest Northern Ireland must leave no stone unturned in saving all of the jobs, not just the 40 that remain.
"The constituency cannot afford to lose investment, skills and opportunity and the government must be unceasing in protecting all of this," Mr Attwood said.
The DUP's Dianne Dodds said employees had been treated disgracefully.
"It is absolutely disgraceful that a large American firm that still has three fully functioning factories in the US can come to Northern Ireland, take grant aid for the establishment of their NI base and then leave a few years later owing their employees wages and salaries," she said.