A 49-year-old man is due in court charged with the murder of Belfast man Robert McCartney.
The 33-year-old father-of-two was stabbed near the city centre
A 36-year-old has also been charged with the attempted murder of his friend Brendan Devine.
Mr McCartney, 33, was stabbed outside a Belfast pub on 30 January and died the following day in hospital.
Both men, who were arrested on Wednesday, are understood to be from Belfast. They are due before the city's magistrates court on Saturday.
One of the men was arrested in Birmingham and brought to Belfast earlier this week.
Mr McCartney's sisters and partner have held a number of meetings with high profile politicians in their campaign for justice over the killing.
In March, they met US President George Bush at the White House in Washington.
They have also held separate meetings with US special envoy to Northern Ireland, Mitchell Reiss and the Irish Taoiseach, Bertie Ahern.