Dozens of dogs, including some from dangerous breeds, have been rescued from farm premises near Katesbridge, animal welfare officers have said.
Police are trying to establish who owns the dogs
The operation, a mile away from where 100 dogs were found on Thursday, saw 50 dogs seized, the Ulster Society for the Prevention of Cruelty to Animals said.
The USPCA's Stephen Philpott said the search was a follow-up to that raid.
Four of the animals are Pit Bulls and are legally classed as a dangerous breed.
The remaining dogs are Boxer, Rottweiler and West Highland Terrier breeds.
Mr Philpott said the animals were being kept in unsuitable conditions and that had prompted Friday's operation.
"We are desperately trying to find out who owns the animals last night and who owns the animals tonight," he said.
Police said 33 adult dogs and 17 juvenile dogs had been seized.
On Thursday, the USPCA said a range of breeds were found in "appalling conditions" at buildings on Circular Road.
The dogs were of various ages and pedigrees, from Rottweilers and Boxers to Jack Russells and terriers.
The operation to remove the animals was hampered when the electricity supply to the farmhouse was cut off.
At one stage, a number of men tried to stop the media taking pictures of the operation.