"Too many times the town has had to stand still in silence but today is all about noise and movement."
Local MP James Gray added that people in the town appreciated the gesture and were "very supportive of it indeed".
Sue Sullivan, from Gloucestershire, is one of those taking part.
She said: "We rode at 1130 GMT and I've never seen so many bikes.
"I'm one of thousands of people who support our girls and boys."
Denise Harris, the founder of Afghan Heroes, said troops on the front line had sent her e-mails backing the event.
She told the BBC: "It boosts morale for them.
"I mean they just are so grateful to the general public for their support and their kindness."
The Bike Run was the idea of 18-year-old biker Elizabeth Stevens.
The ride was organised by Elizabeth Stevens, 18, pictured with her partner
Ms Stevens, a mechanics student at the Central Bedfordshire College, had only planned to ride through the town with a few friends.
"Our local bike club was throwing around the idea of a bike run," she said in January, "so I decided to make a Facebook page, and it's just taken off".
Ms Stevens is riding pillion on her partner's Harley Davidson Sportster.
Laurence Phillips from Afghan Heroes said the event had gathered pace after being posted on the social networking site Facebook.
"It's quite a staggering spectacle and an unbelievable show of support for the troops in Afghanistan and a mark of respect for the town of Wootton Bassett."
Ch Insp Owen Gillard of Wiltshire Police said the force was working with the Ministry of Defence and Wiltshire Council to ensure public safety, with police escorting the bikers and a helicopter at the scene.
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