Bulldozers have begun demolishing the main building at the former home of the BBC in the West Midlands, Pebble Mill.
Pebble Mill was home to the BBC in the West Midlands for 33 years
The famous broadcasting centre, from where programmes such as Top Gear and Dalziel and Pascoe were made, closed for good at the end of 2004.
It is being flattened to make way for a £100m science and technology park.
Development agency Advantage West Midlands (AWM) said the Edgbaston site would be completely clear by November. The BBC is now based at The Mailbox.
AWM has a 95-year lease on the site from freeholders Calthorpe Estates.
The demolition is being carried out by Birmingham-based specialists DSM.
AWM hopes world-class research and development facilities for the medical and healthcare industries will be built in place of Pebble Mill.
It was the home of the BBC for 33 years.
AWM chief executive John Edwards has said: "I have mixed feelings from seeing Pebble Mill being demolished.
"While it means the loss of an historic landmark building for the city, it also means a new era with an exciting high-technology future."