St Cuthbert's name is to be restored to the official title of Durham Cathedral in a dedication service on Sunday.
Durham Cathedral was built more than 900 years ago
Henry VIII stripped the cathedral of its links with the saint 450 years ago.
However, following an application under church law, the name of St Cuthbert, whose body lies in the cathedral, has been reinstated.
The World Heritage Site's formal title will once again become the Cathedral Church of Christ, Blessed Mary the Virgin, and St Cuthbert, of Durham.
Michael Sadgrove, the Dean of Durham, who made the application, will lead a Sung Eucharist at the service.
He said: "North East England is Cuthbert's land and Durham Cathedral is an icon of the region.
"For over 900 years the cathedral has been privileged and proud to be the final resting place of one of England's best-loved saints.
"To restore Cuthbert to the cathedral's name and title is to honour all that he means not only to the north-east but to people across the English-speaking world.
"It's a small but significant piece of history that we are glad to be making."