Tens of thousands of people are due to descend on Tyneside for the 26th annual Great North Run.
Extra safety measures will be in place for the 2006 event
There have been a record number of applications for the famous race between Newcastle and South Shields - around 80,000 for the 50,000 places.
Extra safety measures have been introduced by race organisers Nova after the deaths of four runners in the 2005 event.
England manager Steve McClaren will start the race on Sunday.
Extra trains have been set on for those travelling to the event on Sunday.
Celebrities set to run include Carol Vorderman - who will be "Walking for Whiteley" in memory of Richard Whiteley - and actress Amanda Burton and Chris Tarrant's estranged wife Ingrid.
The race follows the usual route from Newcastle to South Shields via North West Radial, Central Motorway, Tyne Bridge, Felling by-pass, the A194, John Reid Road, King George Road, Prince Edward Road, Redwell Lane and the Coast Road.
People should expect roads throughout the length of the route to be affected by closures and parking restrictions. Diversions will be signposted.
The Great North Run is being broadcast live on BBC One.