Drivers in part of Newcastle city centre are facing changes to the traffic flow from Monday.
The new system has been set up to reduce traffic levels and to improve access to Northumbria University.
It is part of plans by Newcastle City Council to encourage use of public transport and remove unnecessary through-traffic from city centre roads.
Among the measures are a new pedestrian zone outside City Hall and City Pool and changes to a number of junctions.
Drivers will be encouraged to get to the university from the Central Motorway, by travelling along Durant Street to a new signal-controlled junction with College Street.
There will be new signals at the junction of St Mary's Place and College Street and drivers will no longer be able to turn right into College Street.
There will be a pedestrian zone along Northumberland Road outside City Hall and City Pool, with traffic banned between 0930 and 1730 BST.
Cabinet member for planning and transportation, Councillor Danny Marshall, said: "Currently, a great deal of traffic wishing to access the University of Northumbria buildings off College Street have to use a circuitous route through the city centre and this is causing major problems of congestion and certainly is not making the best use of the limited road space available.
"By constructing a new, direct route to and from the university campus we can improve the situation considerably."