The factory in Crawley manufactures prescription medicines
GlaxoSmithKline (GSK) has announced hundreds of people will lose their jobs when it closes its factory in Sussex.
Almost 500 people are expected to be affected when the multinational drugs company's Crawley site closes in 2011.
The company, which is the world's second largest drug maker, blamed the closure on "declining volumes, regulatory delays and patent expiries".
A spokesman said production at the site would continue until the products had been moved to alternative facilities.
The workforce of 493 at the Crawley site, which opened in 1953 and manufactures prescription medicines, are affected by the proposal.
The spokesperson said: "GSK sincerely regrets the potential impact of this proposal in terms of job losses and will do all it can to help staff through this difficult period.
"Implementation of this proposal will be subject to consultation with trade union and staff representatives at the Crawley site. This process will begin immediately."
The factory currently produces medicines to treat Parkinson's disease, heart disease, HIV/AIDS, bacterial skin infections, depression, and hypertension.
In June the company announced it would cut 350 research staff as part of a plan to bolster productivity and cut costs and in February it confirmed it would cut 330 of the 537 jobs at its Cumbria factory.
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