Forty-one post offices across East and West Sussex are to close after a public consultation which ended in December.
More than 200 post office branches will remain open across Sussex
Post Office Ltd said the first would be effective from March, with outreach solutions replacing another two sites.
Gary Herbert, network development manager for Sussex, said: "These are difficult decisions which have not been taken lightly."
Postwatch, which represents Post Office customers, is reviewing the proposed closure of another eight branches.
At the start of the public consultation the Post Office said more than 99% of the area's population would either see no change, or would remain within a mile of a branch.
The government said cuts were needed because the post office network was losing £4m weekly.
During the six-week process, the Post Office received about 6,600 responses and attended 26 meetings with customers.
Mr Herbert said the comments made had been considered very carefully.
"We believe that the amended plan offers our customers across Sussex the best prospect for a sustainable network in the future," he said.
The 41 branches which will close under the Sussex Area Plan are:
Bowness Avenue, 8 Seadown Parade, LancingChurch Road, 137 Lower Church Road, Burgess HillClaremont Road, 23 Claremont Road, SeafordCopthorne, Common Road, Copthorne, CrawleyCrowhurst, Crowhurst, BattleDownlands, 1 Downlands Parade, WorthingDurgates, Durgates, WadhurstElm Grove, 150 Elm Grove, BrightonEtchingham Road, Etchingham Road, EastbourneFairways Estate, 4 Newick Close, SeafordFramfield, The Street, Framfield, UckfieldFranklands Village, Franklands Village, Haywards HeathHailsham Road, Hailsham Road, HeathfieldHeene Road, 62-66 Heene Road, WorthingLondon Road, 91 London Road, Bexhill-On-SeaMount Pleasant, 2 Avis Parade Shops, NewhavenNew England Road, 42-44 America Lane, Haywards HeathNorth Chailey, Haywards Heath Road, LewesNorth Lancing, Mill Road, North LancingOld Shoreham, Upper Shoreham Road, Shoreham-By-SeaPreston, 221 Preston Road, BrightonPreston Road, 13 Preston Road, BrightonRichardson Road, Richardson Road, HoveSlindon, Slindon Top Road, Slindon, ArundelSouth Lancing, 83 South Street, South LancingSouthern Cross, 86 Trafalgar Road, Portslade, BrightonSt Johns Common, 95 London Road, Burgess HillSt Leonards Green, 45 Springfield Road, St LeonardsThe Broadway, 1/2 The Broadway, EastbourneThe Parade, 40 Broadwater Road, WorthingThe Strand, The Strand, WorthingTilling Green, Tilling Green News, 45 Lea Avenue, RyeTown Row, Yew Tree Lane - Town Row, CrowboroughTrafalgar Street, 8 Trafalgar Street, BrightonUpper Dicker, Coldharbour Road, Upper Dicker, HailshamWannock, 41 Farmlands Way, PolegateWarnham, 3 Church Street, Warnham, HorshamWashingtonThe Frankland Arms, London Road, PulboroughWest Beach, 132 Beach Green, Shoreham-By-SeaWhite Rock, 32-33 White Rock, HastingsWillingdon, 116 Wish Hill, Willingdon, Eastbourne
Two branches to be replaced by an outreach solution are the Barns Green post office in Horsham, and Plaistow in Billingshurst.
The future of the following eight branches is still under consideration:
Marine Parade, 15/17 Seaside, EastbourneOld Town Hastings, 70 George Street, HastingsCollington, 2 Collington Mansions, Bexhill-On-SeaLandport, 34 Lee Road, LewesStation Road, 12-14 Station Road, HorshamQueen Street, 70 Queen Street, HorshamSt Leonards Road, 15 St Leonards Road, HorshamNorth Parade, 24 North Parade, Horsham
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