Plans to turn the former Tolly Cobbold brewery in Ipswich into luxury flats have been rejected.
Councillors were concerned the new homes would be too close to nearby industrial areas.
Developers wanted to convert the listed Cliff Brewery building into 26 apartments and build another 42 new homes in five to 11 storey blocks.
Borough councillors threw out the plans, which had been recommended for refusal, at a meeting on Wednesday.
The Health and Safety Executive recommended against the development, saying the surrounding industrial areas made the site unsuitable for residential use.
There was also concern about potentially hazardous materials being used by a company near to the site.
The brewery in Cliff Road closed in 2002 when Tolly Cobbold was taken over by Ridley's.