A lane is being closed for three months to allow for the safe crossing of hundreds of migratory toads.
Norton Wood Lane in Clevedon is being closed by North Somerset Council for the first time, following advice from conservationists and highways staff.
Up to 1,000 toads are expected to cross from a woodland to a fenland.
Road closure signs will be up from January 2006 advising motorists who need to use the road to drive with extra caution.
A council spokeswoman said: "We were approached by someone who knew about these things and who said these toads were being killed on this road."
Earlier this year during a similar scheme, 1,729 toads, 117 frogs and 188 newts were captured by volunteers and helped across a road in Bath.
The crossing at Charlcombe Lane has been running for several years.