Residents at risk of flooding in Oxford are being told to leave their homes as water levels are expected to rise.
David Cameron praised the emergency services in Witney
Severe flood warnings have been issued for several areas across Oxfordshire by the Environment Agency.
Homes in Oxford, Abingdon, Kidlington and Bladon have already been flooded and conditions are due to deteriorate.
Oxfordshire County Council has closed some roads to prepare for localised flooding and is issuing residents with sandbags to protect their homes.
Emergency planners are warning people in Eynsham, Standlake, Northmoor, Shipton-under-Wychwood and Witney to sandbag their properties and prepare to leave if necessary.
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In Witney, Bridge Street and Mill Street are closed to traffic as both streets are flooded and impassable. Homes are being evacuated.
In the Charlbury area, the River Evenlode has burst its banks and a number of properties have been affected, and vehicles stranded.
In Shipton-under-Wychwood 50 residents of the Old Prebendal Care Home were moved to the first floor on Saturday night and have now been removed.
John Parry, Oxfordshire County Council's director for community safety, said: "The general advice is that people should make one of two decisions - either stay at home and consider moving upstairs, or consider staying with family or friends."
Oxford's Botley and Abingdon Road areas and parts of nearby Abingdon, Bladon and Kidlington were, as predicted, flooded this morning, a fire service spokeswoman said.
"All the areas the Environment Agency said would flood are now under water," she said.
Conservative Leader David Cameron visited Witney, the main town in his Oxfordshire constituency, to survey the flooding.
Mr Cameron said: "It is very grim, but one's impression here is that people are reacting in a great way. The emergency services here have done a magnificent job."