The world's first research centre dedicated to studying the pain caused by arthritis - and finding better treatments - is planned for Nottingham.
The £5.5m Arthritis Research Campaign National Pain Centre will bring experts together to improve their understanding of the disease and develop treatments.
It is funded by the Arthritis Research Campaign and the city's university.
People with osteoarthritis in Nottingham are being recruited to help with research.
Pain affects millions
The team hopes to gain new insights into how arthritis pain is experienced and probe its causes over the next five years.
The centre's director Dr David Walsh, from the University of Nottingham's Department of Academic Rheumatology, said: "There is a huge unmet need for better pain relief for people with arthritis."
Professor Alan Silman, medical director of the Arthritis Research Campaign, said: "Pain is the number one concern for all patients with arthritis and there have been too few recent advances in how to manage it.
"Our new centre is charged with a truly innovative approach."
Osteoarthritis, the most common form of the disease, affects millions of people in the UK and has no cure.
Rheumatoid arthritis affects more than 400,000 people.