The Yorkshire Air Ambulance is to move from its base at Leeds-Bradford Airport to North Yorkshire later this year.
Richard Hammond was flown to hospital by the air ambulance
The helicopter, which has been based in West Yorkshire since the service began six years ago, is expected to get a new home at Tockwith airfield near York.
The charity says it will be able to better serve the region from its new location, which also benefits from clearer weather than Leeds-Bradford.
A fundraising drive has been launched to finance a new headquarters.
About £250,000 was donated to the charity last year after its rescue of Top Gear presenter Richard Hammond following his high-speed car crash near York in September.
That money allowed the service to announce plans to buy a second helicopter so that it can provide 24-hour coverage.