The number of superbug cases at a health trust's hospitals has been cut by a third over the last three years.
Over exposure to some antibiotics builds MRSA resistance
Norfolk and Norwich University Hospital chiefs have been told MRSA cases at its units around the county have fallen from 64 cases in 2003 to 48 in 2006.
A clinical audit of patients has also confirmed about 80% of patients get the infection before coming into hospital.
A screening service is to be introduced to identify affected patients before they are admitted.
Director of infection control and consultant microbiologist, Dr Judith Richards, said: "Our extensive work to limit the spread of healthcare associated infections is reflected in the fact our hospitals continue to have among the very lowest rates in East Anglia."
She added: "We are working with primary care to address that fact that the majority of people we now see with infection seem to be community-acquired."
MRSA is a close relation of the staphylococcus organisms that often live on people's skin.
Nearly a third of the population in the UK carry it on their skin or in their nose.