Non-touch technique training has played a role in reducing infection
Improved hygiene procedures at a Greater Manchester health authority have resulted in its hospitals staying free of MRSA for 12 months.
Trafford Healthcare NHS Trust has clamped down on hand-washing and brought in MRSA patient screening.
In 2008 it also introduced techniques to treat patients without touching potentially infected parts of clinical instruments.
Figures for C. difficile have also reduced under the regime.
The trust's director of nursing and operations Morag Olsen said: "This reduction in infection rates really is a tremendous achievement and credit must go to all the staff who have brought about these results.
"The dramatic fall in both MRSA and C. difficile is testament to the rigorous infection prevention and control techniques we have in place.
"To have no MRSA for more than a year is remarkable, and there is no reason we cannot aim for no cases in the whole of 2010 to 2011."
Out of almost 270,000 patients treated in Trafford's hospitals between 1 April 2009 and 31 March 2010, there was one case of MRSA.
There were 56 cases of potentially fatal C. difficile for 2008/9, falling below the target of 68 cases.
The trust runs Trafford General Hospital, Altrincham General Hospital and Stretford Memorial Hospital.