A section of road, dubbed the most dangerous in Britain, is to be monitored with average speed cameras.
There have been 264 casualties on the Cat and Fiddle road - the A537 between Macclesfield and Buxton - since 2001.
Of those killed or seriously injured, 70% were motorcyclists, Cheshire Safer Roads Partnership said.
Work to install seven cameras, which will record the average speed of vehicles on the 50mph road, is due to begin this week.
The Cheshire Safer Roads Partnership said the road, which links Cheshire and Derbyshire, is consistently identified by independent surveys as the most dangerous in Britain.
The Road Safety Foundation pinpointed the road as the country's most dangerous in a survey in 2008.
Lee Murphy, manager of Cheshire Safer Roads Partnership, said: "We want all road users to come and enjoy this scenic route responsibly and lawfully.
"Unfortunately, a minority of riders treat the road with a racetrack mentality - we have recorded bikers riding at speeds of 130mph.
"This is not a knee-jerk reaction because we have tried all other measures.
"Short of closing the road, we couldn't see any viable alternatives to the average speed cameras to reduce the number of casualties along the Cat and Fiddle."
The cameras are expected to be in use by the end of March. They have been designed to minimize the impact on the landscape.