The soap opera was first broadcast in December 1960
The cobbled road of ITV's flagship drama Coronation Street could be demolished after talks resumed to move it to Salford Quays.
ITV confirmed it was in talks with the owners of the MediaCity development, Peel Media, about the plan.
Previous negotiations broke down between the two parties in March.
MediaCity, which opens in 2011, is 36-acres in size and has cost £600m to build. The BBC will be the main tenant, with 2,500 jobs moving from London.
Coronation Street, which is filmed at ITV Studios behind the Museum of Science and Industry, was first broadcast on 9 December 1960.
The famous road, which has had viewers gripped by the extra-marital affairs, fights, and everyday life of its residents, had been a tourist attraction for decades.
Talks about moving the set were severed last year when ITV pulled out stating Peel Media had "dramatically scaled back its financial commitment".
An ITV spokesman would not comment on how successful the talks have been so far.
"Talks have resumed again into the future site of Coronation Street, but we cannot comment any further than that at this stage."