The children's hospital will be one of the biggest in the UK
The first stage of moving children's treatment at Manchester hospitals has started after Booth Hall's Accident and Emergency unit closed.
The hospital department is now based at North Manchester General Hospital.
A paediatric emergency department will open at the new children's hospital on Oxford Road in Manchester city centre on 16 June.
It admits patients from premature babies to 16-year-olds who require intensive care facilities.
Specialist services and clinics are also being based at the new 370-bed Royal Manchester Children's Hospital.
Booth Hall Infirmary opened in 1909 and was designated as a children's hospital in 1915. The entire site closes on 11 June.
The new Royal Manchester Children's Hospital is part of a £500m development of four hospitals in Oxford Road.
The new children's hospital integrates Booth Hall Children's Hospital and the Royal Manchester Children's Hospital, Pendlebury.
Manchester Royal Infirmary, Saint Mary's Hospital for Women and Children and Manchester Royal Eye Hospital are all being revamped to become part of the complex.
The whole development will cover a total area of over 265,000sq m - nearly twice the size of the Trafford Centre.
It will have more than 1,100 beds and 1,600 car park spaces.