A 40-year-old woman and her 12-year-old son have gone missing from their home in Greater Manchester.
Alison Davies and her son Ryan were last seen on Tuesday
Police said on Friday they were growing increasingly concerned for the welfare of Alison Davies and her son Ryan who are from Stockport.
Ryan has autism and needs medication. Ms Davies suffers from depression and is not thought to have her medication.
They were last seen on Tuesday at her mother's house in Marple. Police believe Ms Davies may be in Humberside.
Officers think she may have travelled, or be travelling, to the Humberside area on public transport.
They are working closely with Humberside Police and British Transport Police in the search.
Ms Davies is described as white, 5ft 4in tall and of slim build. She has shoulder length brown hair and speaks with a southern accent.
She may be wearing dark coloured sports clothes.
Ryan is described as 5ft 2in tall and of heavy build, with short, blond hair. He may be wearing loose-fitting sports clothes.