Salford City Reds rugby league club have been given the go-ahead to build a new 20,000 seater stadium.
John Prescott has to grant final permission to the plans
The city council approved plans for the arena, four-star hotel, shops and casino complex on Thursday.
The club wants to move to Barton after more than 100 years playing at The Willows in Weaste.
The plans include provision for a super casino but can be downscaled if, as expected, the government only approves one Las Vegas-style casino.
A smaller scale casino would attract 1,500 new jobs to the area, it has been predicted.
Fans put forward an online petition with more than 1,000 signatures in favour of the move.
But 80 letters of objection from residents were received citing concerns over noise pollution, drunken behaviour, and the impact of the retail development on shops in nearby Eccles.
The club hope a new stadium will help propel it into "one of the great forces in the world of rugby league".
Deputy prime minister John Prescott has the final say on planning permission before building work can begin.