Police have named a 15-year-old girl from Rochdale who died after a suspected heroin overdose.
Police are waiting for toxicology test results on Victoria Agoglia
Victoria Agoglia, known to her family and friends as Vicky Byrne (her stepfather's surname), was taken ill on Saturday and died on Monday shortly after 1700 BST in the Royal Manchester Children's Hospital, Pendlebury.
A post mortem examination on Tuesday failed to find the cause of death - Greater Manchester Police are awaiting toxicology test results.
Two 22-year-old men from Rochdale have been arrested and will be questioned by police.
A man and woman were arrested at the weekend and released on police bail.
A statement from her grandmother, Joan Agoglia, and aunt, Tracey Agoglia, said: "Victoria was a loving 15-year-old who was always full of life.
"She had always wanted to get a job as a hairdresser and she also wanted to be a model."
It added: "Victoria was a typical teenager who will be greatly missed by all those that knew her."
Vicky had been in the care of Manchester Social Services since her mother died in 1997.
She lived at a privately run residential home for children with complex needs in Rochdale.
She had run away up to 50 times in the past, the final time being last Wednesday.
Manchester Social Services said it had done everything possible to keep her safe.
Spokeswoman Pauline Newman said: "In this particular instance, the care planning appears to have been consistent with what her needs were and what we knew about her.
"The staff who cared for her in the residential home or who were more directly involved with her are very upset and obviously very saddened.
"They are really feeling concerned for her family and the tragedy of a young life ending in this way."