A secondary school will be based in the main stadium
There is now a "clear vision" for the use of London's Olympic site after the 2012 Games, the mayor has said.
Boris Johnson said detailed plans for the long-term use of the east London site would deliver a lasting legacy.
They include using the site to house a sports academy, a school, an elite sports training centre and housing.
Post-2012 plans for the vast site in Stratford were unveiled by the mayor, Olympics Minister Tessa Jowell and communities secretary Hazel Blears.
Key to the £9.3b building project is the plan to host world-class athletics championships and leisure events.
Johnson said his earlier concerns about a lack of "clear vision" have been allayed by the new plans.
"Today, after many months of hard work, I am delighted to be able to present that clear vision," he said.
"It shows how we plan to use the investment in new transport, new infrastructure and new world-class facilities as the backbone of a fantastic new place to live, raise a family, do business, study, work and visit."
A secondary school will be based in the main stadium, which will also be reduced from 80,000 seats to 25,000.
Until now legacy has been put on some sort of pedestal by all involved in the Games - acknowledged in hallowed terms but otherwise ignored
Baroness Jo Valentine, London First
The plans will now be subjected to six weeks of public consultation.
The stadium will also house the English Institute of Sport and the National Skills Academy for sports and leisure industries.
Other sporting venues, including the Aquatics Centre and Velodrome, will be kept for community and elite sporting use.
The plans also allow for new facilities, such as playing areas for football, hockey, tennis and mountain biking.
The overall goal is to prevent the site from slipping into disrepair after the Games and to fulfil the mandate to have both an economic and sporting legacy for deprived parts of east London.
There are also proposals to build 10,000 new homes in the area, in addition to those in the Olympic Village.
Baroness Jo Valentine, chief executive of London First, said the detailed plans were welcome by the city's business interests.
"At last, real progress on legacy," she said.
"Until now legacy has been put on some sort of pedestal by all involved in the Games - acknowledged in hallowed terms but otherwise ignored."
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