Brixton's Tube station will be closed for nine days to remove asbestos from the south London terminal.
Replacement bus services will operate
The station, which is at the end of the Victoria Line, shut on Saturday and will re-open on 17 April.
Asbestos dust can cause serious illness if inhaled but London Underground (LU) said it was safe in its current state.
Trains will terminate at Stockwell and a high frequency rail replacement bus service will operate between Stockwell and Brixton.
In 2003 the station was closed for three weeks after asbestos was found during work to escalators and lifts.
John Doyle, General Manager of the Victoria Line, said: "There is no safety risk to our customers and staff as the asbestos has not been disturbed and in that state it is safe. Air quality is being continually monitored by our asbestos control unit."
Improving the station is part of Transport for London's five year, £10bn plan to upgrade public transport.
Brixton station is estimated to have an average of 12,000 passengers travelling through it every day.