Thieves stole 2,500 Simpsons Scalextric sets from the back of a lorry parked near motorway services in Kent.
The boxes show Bart and Homer Simpson skateboarding
The games, worth £75,000, were taken from a trailer at Farthing Corner, near services on the M2 on Monday lunchtime.
The Simpsons Skateboard chase sets are in boxes showing Bart and Homer Simpson on skateboards and were being delivered to the Margate base of makers Hornby.
Kent Police want anyone with information about the theft to contact them or Crimestoppers.
Nick Cole, operations manager for Hornby, said it was not clear how the thieves had got into the lorry.
He said: "We've got a lot of stock in the market place, so hopefully there's not going to be too many disappointed kids.
"I don't know what Homer would say. Probably 'd'oh!'"
The Simpsons Scalextric, which features the show's characters riding skateboards, has been one of Hornby's biggest sellers over the past two years and costs about £30.